View source for 5cac

[[Image:5cac.gif|left|200px]]

 {{Structure
|PDB= 5cac |SIZE=350|CAPTION= <scene name='initialview01'>5cac</scene>, resolution 2.2&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=SO3:SULFITE ION'>SO3</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] 
|GENE= 
}}

'''REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION'''


==Overview==
The structure of human erythrocytic carbonic anhydrase II has been refined by constrained and restrained structure-factor least-squares refinement at 2.0 A resolution. The conventional crystallographic R value is 17.3%. Of 167 solvent molecules associated with the protein, four are buried and stabilize secondary structure elements. The zinc ion is ligated to three histidyl residues and one water molecule in a nearly tetrahedral geometry. In addition to the zinc-bound water, seven more water molecules are identified in the active site. Assuming that Glu-106 is deprotonated at pH 8.5, some of the hydrogen bond donor-acceptor relations in the active site can be assigned and are described here in detail. The O gamma 1 atom of Thr-199 donates its proton to the O epsilon 1 atom of Glu-106 and can function as a hydrogen bond acceptor only in additional hydrogen bonds.

==Disease==
Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611492 611492]]

==About this Structure==
5CAC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CAC OCA]. 

==Reference==
Refined structure of human carbonic anhydrase II at 2.0 A resolution., Eriksson AE, Jones TA, Liljas A, Proteins. 1988;4(4):274-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3151019 3151019]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Habash, D.]]
[[Category: Harrop, S.]]
[[Category: Helliwell, D R.]]
[[Category: Liljas, A.]]
[[Category: Lindahl, M.]]
[[Category: SO3]]
[[Category: ZN]]
[[Category: lyase(oxo-acid)]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:11:40 2008''