View source for 2ypr

==Crystal structure of the DNA binding ETS domain of human protein FEV==
<StructureSection load='2ypr' size='340' side='right' caption='[[2ypr]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ypr RCSB], [http://www.ebi.ac.uk/pdbsum/2ypr PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry.  A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. 
== Function ==
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Allerston, C K]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Cooper, C]]
[[Category: Delft, F Von]]
[[Category: Edwards, A]]
[[Category: Gileadi, O]]
[[Category: Krojer, T]]
[[Category: Vollmar, M]]
[[Category: Weigelt, J]]
[[Category: Transcription]]