View source for 2oq1

[[Image:2oq1.gif|left|200px]]

 {{Structure
|PDB= 2oq1 |SIZE=350|CAPTION= <scene name='initialview01'>2oq1</scene>, resolution 1.9&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=PB:LEAD (II) ION'>PB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] 
|GENE= 
}}

'''Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide'''


==Overview==
The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor.

==Disease==
Known diseases associated with this structure: Immunodeficiency due to defect in CD3-zeta OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186780 186780]], Selective T-cell defect OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176947 176947]]

==About this Structure==
2OQ1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQ1 OCA]. 

==Reference==
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor., Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, et al., Nature. 1995 Sep 7;377(6544):32-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7659156 7659156]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Protein complex]]
[[Category: Green, J.]]
[[Category: Hatada, M H.]]
[[Category: Laird, E R.]]
[[Category: Morgenstern, J.]]
[[Category: Ram, M K.]]
[[Category: PB]]
[[Category: tandem sh2 domain]]
[[Category: tyrosine kinase]]
[[Category: zap-70]]

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