View source for 2obs

[[Image:2obs.gif|left|200px]]

 {{Structure
|PDB= 2obs |SIZE=350|CAPTION= <scene name='initialview01'>2obs</scene>, resolution 2.0&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''Crystal Structures of P Domain of Norovirus VA387 in Complex with Blood Group Trisaccharides type A'''


==Overview==
Noroviruses are one of the major causes of nonbacterial gastroenteritis epidemics in humans. Recent studies on norovirus receptors show that different noroviruses recognize different human histo-blood group antigens (HBGAs), and eight receptor binding patterns of noroviruses have been identified. The P domain of the norovirus capsids is directly involved in this recognition. To determine the precise locations and receptor binding modes of HBGA carbohydrates on the viral capsids, a recombinant P protein of a GII-4 strain norovirus, VA387, was cocrystallized with synthetic type A or B trisaccharides. Based on complex crystal structures observed at a 2.0-A resolution, we demonstrated that the receptor binding site lies at the outermost end of the P domain and forms an extensive hydrogen-bonding network with the saccharide ligand. The A and B trisaccharides display similar binding modes, and the common fucose ring plays a key role in this interaction. The extensive interface between the two protomers in a P dimer also plays a crucial role in the formation of the receptor binding interface.

==About this Structure==
2OBS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Nairovirus Nairovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBS OCA]. 

==Reference==
Structural basis for the recognition of blood group trisaccharides by norovirus., Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z, J Virol. 2007 Jun;81(11):5949-57. Epub 2007 Mar 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17392366 17392366]
[[Category: Nairovirus]]
[[Category: Single protein]]
[[Category: Cao, S.]]
[[Category: Li, X.]]
[[Category: Rao, Z.]]
[[Category: blood group trisaccharides type some]]
[[Category: crystal structure]]
[[Category: norovirus va387]]
[[Category: p domain]]

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