View source for 2mjc

==Zn-binding domain of eukaryotic translation initiation factor 3, subunit G==
<StructureSection load='2mjc' size='340' side='right' caption='[[2mjc]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mjc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MJC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjc RCSB], [http://www.ebi.ac.uk/pdbsum/2mjc PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/EIF3G_HUMAN EIF3G_HUMAN]] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA. 
__TOC__
</StructureSection>
[[Category: Al-Abdul-Wahid, M]]
[[Category: Gehring, K]]
[[Category: Kozlov, G]]
[[Category: Menade, M]]
[[Category: Xie, J]]
[[Category: Metal binding protein]]
[[Category: Zinc-binding domain]]