View source for 4msv

==Crystal structure of FASL and DcR3 complex==
<StructureSection load='4msv' size='340' side='right' caption='[[4msv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4msv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MSV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4en0|4en0]], [[3mhd|3mhd]], [[4j6g|4j6g]], [[4kgg|4kgg]], [[4kgq|4kgq]], [[3k51|3k51]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF6B, DCR3, TR6, UNQ186/PRO212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FASLG, APT1LG1, CD95L, FASL, TNFSF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4msv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4msv RCSB], [http://www.ebi.ac.uk/pdbsum/4msv PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry. 
== Function ==
[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref>  [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref>   The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref>  

==See Also==
*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Almo, S C]]
[[Category: Bhosle, R C]]
[[Category: Bonanno, J B]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
[[Category: Liu, W]]
[[Category: Structural genomic]]
[[Category: Nathenson, S G]]
[[Category: Ramagopal, U A]]
[[Category: Zhan, C]]
[[Category: Atoms-to-animals: the immune function network]]
[[Category: Bind tnf receptor fa]]
[[Category: Cd95l]]
[[Category: Cytokine]]
[[Category: Dcr3]]
[[Category: Fas ligand]]
[[Category: Fasl]]
[[Category: Ifn]]
[[Category: Immune system]]
[[Category: Immunity]]
[[Category: Jelly-roll fold]]
[[Category: Membrane]]
[[Category: Nysgrc]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Research consortium]]
[[Category: Secreted protein]]
[[Category: Tnf]]
[[Category: Tnf supe cd95l]]
[[Category: Tnf superfamily]]
[[Category: Tnf6]]
[[Category: Tnfr]]