View source for 2foy

[[Image:2foy.gif|left|200px]]

 {{Structure
|PDB= 2foy |SIZE=350|CAPTION= <scene name='initialview01'>2foy</scene>, resolution 1.55&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=B30:{2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER'>B30</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] 
|GENE= CA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}

'''Human Carbonic Anhydrase I complexed with a two-prong inhibitor'''


==Overview==
The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.

==About this Structure==
2FOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOY OCA]. 

==Reference==
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity., Jude KM, Banerjee AL, Haldar MK, Manokaran S, Roy B, Mallik S, Srivastava DK, Christianson DW, J Am Chem Soc. 2006 Mar 8;128(9):3011-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16506782 16506782]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Banerjee, A L.]]
[[Category: Christianson, D W.]]
[[Category: Haldar, M K.]]
[[Category: Jude, K M.]]
[[Category: Mallik, S.]]
[[Category: Manokaran, S.]]
[[Category: Roy, B.]]
[[Category: Srivastava, D K.]]
[[Category: B30]]
[[Category: ZN]]
[[Category: copper]]
[[Category: inhibitor]]
[[Category: lyase]]
[[Category: zinc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:55:04 2008''