View source for 3nmx

==Crystal structure of APC complexed with Asef==
<StructureSection load='3nmx' size='340' side='right' caption='[[3nmx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nmx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NMX FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nmw|3nmw]], [[3nmz|3nmz]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nmx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nmx RCSB], [http://www.ebi.ac.uk/pdbsum/3nmx PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ARHG4_HUMAN ARHG4_HUMAN]] Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.<ref>PMID:10947987</ref> <ref>PMID:12598901</ref> <ref>PMID:17145773</ref> <ref>PMID:17599059</ref> <ref>PMID:19893577</ref>  
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Chen, L]]
[[Category: Gao, L]]
[[Category: Lin, K]]
[[Category: Wu, G]]
[[Category: Zhang, Z]]
[[Category: Cell adhesion-cell cycle complex]]
[[Category: Protein-protein complex]]