View source for 4juk

==Crystal structure of H5N1 influenza virus hemagglutinin, clade 2.3.2.1==
<StructureSection load='4juk' size='340' side='right' caption='[[4juk]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4juk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4juk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4juk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4juk RCSB], [http://www.ebi.ac.uk/pdbsum/4juk PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/B7NWR4_9INFA B7NWR4_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS000149_004_327643] 
__TOC__
</StructureSection>
[[Category: Coop, T]]
[[Category: DuBois, R M]]
[[Category: Heath, R J]]
[[Category: Reddivari, M]]
[[Category: Russell, C J]]
[[Category: White, S W]]
[[Category: Zaraket, H]]
[[Category: Glycosylation]]
[[Category: Hemagglutinin]]
[[Category: Sialic acid]]
[[Category: Viral envelope protein]]
[[Category: Viral fusion protein]]
[[Category: Viral protein]]