View source for 3plc

==Crystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannah==
<StructureSection load='3plc' size='340' side='right' caption='[[3plc]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3plc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PLC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3plc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3plc RCSB], [http://www.ebi.ac.uk/pdbsum/3plc PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CTX27_OPHHA CTX27_OPHHA]] Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2). It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it. At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min).<ref>PMID:17616557</ref>  

==See Also==
*[[Cardiotoxin|Cardiotoxin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ophiophagus hannah]]
[[Category: Kini, R M]]
[[Category: Qingxiang, S]]
[[Category: Roy, A]]
[[Category: Sivaraman, J]]
[[Category: Beta-cardiotoxin]]
[[Category: Beta-sheet]]
[[Category: Novel cardiotoxin]]
[[Category: Toxin]]