View source for 2arw

[[Image:2arw.gif|left|200px]]

 {{Structure
|PDB= 2arw |SIZE=350|CAPTION= <scene name='initialview01'>2arw</scene>
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor'''


==Overview==
The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.

==About this Structure==
2ARW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. 

==Reference==
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16972794 16972794]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Dingley, A J.]]
[[Category: Grotzinger, J.]]
[[Category: Hecht, O.]]
[[Category: Ozbek, S.]]
[[Category: Rose-John, S.]]
[[Category: Schwantner, A.]]
[[Category: fibronectin-type iii like]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:53:09 2008''