View source for 1vrq

[[Image:1vrq.gif|left|200px]]

 {{Structure
|PDB= 1vrq |SIZE=350|CAPTION= <scene name='initialview01'>1vrq</scene>, resolution 2.20&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=FON:FOLINIC+ACID'>FON</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene> and <scene name='pdbligand=DMG:N,N-DIMETHYLGLYCINE'>DMG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Sarcosine_oxidase Sarcosine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.1 1.5.3.1] 
|GENE= 
}}

'''Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid'''


==Overview==
Sarcosine oxidase from Corynebacterium sp. U-96 is a heterotetrameric enzyme. Here we report the crystal structures of the enzyme in complex with dimethylglycine and folinic acid. The alpha subunit is composed of two domains, contains NAD(+), and binds folinic acid. The beta subunit contains dimethylglycine, FAD, and FMN, and these flavins are approximately 10A apart. The gamma subunit is in contact with two domains of alpha subunit and has possibly a folate-binding structure. The delta subunit contains a single atom of zinc and has a Cys(3)His zinc finger structure. Based on the structures determined and on the previous works, the structure-function relationship on the heterotetrameric sarcosine oxidase is discussed.

==About this Structure==
1VRQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Corynebacterium_sp. Corynebacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRQ OCA]. 

==Reference==
Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96., Ida K, Moriguchi T, Suzuki H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):359-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15946648 15946648]
[[Category: Corynebacterium sp.]]
[[Category: Protein complex]]
[[Category: Sarcosine oxidase]]
[[Category: Ida, K.]]
[[Category: Moriguchi, T.]]
[[Category: Suzuki, H.]]
[[Category: DMG]]
[[Category: FAD]]
[[Category: FMN]]
[[Category: FON]]
[[Category: NAD]]
[[Category: SO4]]
[[Category: ZN]]
[[Category: flavoenzyme]]
[[Category: heterotetrameric sarcosine oxidase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:48:52 2008''