View source for 1sxr

[[Image:1sxr.gif|left|200px]]

 {{Structure
|PDB= 1sxr |SIZE=350|CAPTION= <scene name='initialview01'>1sxr</scene>, resolution 1.56&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY= 
|GENE= 
}}

'''Drosophila Peptidoglycan Recognition Protein (PGRP)-SA'''


==Overview==
Peptidoglycan recognition proteins (PGRPs) form a recently discovered protein family, which is conserved from insect to mammals and is implicated in the innate immune system by interacting with/or degrading microbial peptidoglycans (PGNs). Drosophila PGRP-SA is a member of this family of pattern recognition receptors and is involved in insect Toll activation. We report here the crystal structure of PGRP-SA at 1.56 A resolution, which represents the first example of a "recognition" PGRP. Comparison with the catalytic Drosophila PGRP-LB reveals an overall structure conservation with an L-shaped hydrophilic groove that is likely the PGN carbohydrate core binding site, but further suggests some possible functional homology between recognition and catalytic PGRPs. Consistent with sequence analysis, PGRP-SA does not contain the canonical zinc-binding residues found in catalytic PGRPs. However, substitution of the zinc-binding cysteine residue by serine, along with an altered coordinating histidine residue, assembles a constellation of residues that resembles a modified catalytic triad. The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs.

==About this Structure==
1SXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXR OCA]. 

==Reference==
Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution., Reiser JB, Teyton L, Wilson IA, J Mol Biol. 2004 Jul 16;340(4):909-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15223330 15223330]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Reiser, J B.]]
[[Category: Teyton, L.]]
[[Category: Wilson, I A.]]
[[Category: EDO]]
[[Category: SO4]]
[[Category: innate immunity]]
[[Category: pattern recognition receptor]]
[[Category: peptidoglycan]]
[[Category: toll pathway]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:11:01 2008''