View source for 1qfh

[[Image:1qfh.jpg|left|200px]]

 {{Structure
|PDB= 1qfh |SIZE=350|CAPTION= <scene name='initialview01'>1qfh</scene>, resolution 2.2&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''DIMERIZATION OF GELATION FACTOR FROM DICTYOSTELIUM DISCOIDEUM: CRYSTAL STRUCTURE OF ROD DOMAINS 5 AND 6'''


==Overview==
Gelation factor (ABP120) is one of the principal actin-cross-linking proteins of Dictyostelium discoideum. The extended molecule has an N-terminal 250-residue actin-binding domain and a rod constructed from six 100-residue repeats that have an Ig fold. The ability to dimerize is crucial to the actin cross-linking function of gelation factor and is mediated by the rod in which the two chains are arranged in an antiparallel fashion. We report the 2.2 A resolution crystal structure of rod domains 5 and 6, which shows that dimerization is mediated primarily by rod domain 6 and is the result of a double edge-to-edge extension of beta-sheets. Thus, contrary to earlier proposals, the chains of the dimeric gelation factor molecule overlap only within domain 6, and domains 1-5 do not pair with domains from the other chain. This information allows construction of a model of the gelation factor molecule and suggests how the chains in the related molecule filamin (ABP280) may interact.

==About this Structure==
1QFH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFH OCA]. 

==Reference==
Structural basis for dimerization of the Dictyostelium gelation factor (ABP120) rod., McCoy AJ, Fucini P, Noegel AA, Stewart M, Nat Struct Biol. 1999 Sep;6(9):836-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10467095 10467095]
[[Category: Dictyostelium discoideum]]
[[Category: Single protein]]
[[Category: Fucini, P.]]
[[Category: Mccoy, A J.]]
[[Category: Noegel, A A.]]
[[Category: Stewart, M.]]
[[Category: abp-120]]
[[Category: actin binding protein]]
[[Category: gelation factor]]
[[Category: immunoglobulin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:44 2008''