View source for 1qas

[[Image:1qas.gif|left|200px]]

 {{Structure
|PDB= 1qas |SIZE=350|CAPTION= <scene name='initialview01'>1qas</scene>, resolution 2.4&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] 
|GENE= 
}}

'''1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1'''


==Overview==
The structure of the PH-domain truncated core of rat phosphoinositide-specific phospholipase C-delta 1 has been determined at 2.4 A resolution and compared to the structure previously determined in a different crystal form. The stereochemical relationship between the EF, catalytic, and C2 domains is essentially identical. The Ca2+ analogue Sm3+ binds at two sites between the jaws of the C2 domain. Sm3+ binding ejects three lysine residues which bridge the gap between the jaws and occupy the Ca2+ site in the apoenzyme, triggering a conformational change in the jaws. The distal sections of the C2 jaws move apart, opening the mouth by 9 A and creating a gap large enough to bind a phospholipid headgroup.

==About this Structure==
1QAS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QAS OCA]. 

==Reference==
C2 domain conformational changes in phospholipase C-delta 1., Grobler JA, Essen LO, Williams RL, Hurley JH, Nat Struct Biol. 1996 Sep;3(9):788-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8784353 8784353]
[[Category: Phosphoinositide phospholipase C]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Grobler, J A.]]
[[Category: Hurley, J H.]]
[[Category: calcium-binding]]
[[Category: hydrolase]]
[[Category: lipid degradation]]
[[Category: transducer]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:35:13 2008''