View source for 1ido

[[Image:1ido.gif|left|200px]]<br />
<applet load="1ido" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1ido, resolution 1.7&Aring;" />
'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''<br />

==Overview==
We have determined the high resolution crystal structure of the A domain, from the alpha chain of integrin CR3. The domain adopts a classic, alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site, at its surface. One of the coordinating ligands is the glutamate side, chain from another A domain molecule. We suggest that this site represents, a general metal ion-dependent adhesion site (MIDAS) for binding protein, ligands. We further propose that the beta subunits of integrins contain a, MIDAS motif within a modified A domain. Our crystal structure will allow, reliable models to be built for other members of the A domain superfamily, and should facilitate development of novel adhesion modulatory drugs.

==About this Structure==
1IDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: MG. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA]. 

==Reference==
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7867070 7867070]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Lee, J.O.]]
[[Category: Liddington, R.]]
[[Category: MG]]
[[Category: cell adhesion protein]]
[[Category: cytoskeleton]]
[[Category: extracellular matrix]]
[[Category: glycoprotein]]
[[Category: integrin]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 12:31:14 2007''