View source for 1nbs

[[Image:1nbs.gif|left|200px]]

 {{Structure
|PDB= 1nbs |SIZE=350|CAPTION= <scene name='initialview01'>1nbs</scene>, resolution 3.15&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=PB:LEAD (II) ION'>PB</scene>
|ACTIVITY= 
|GENE= 
}}

'''Crystal structure of the specificity domain of Ribonuclease P RNA'''


==Overview==
RNase P is the only endonuclease responsible for processing the 5' end of transfer RNA by cleaving a precursor and leading to tRNA maturation. It contains an RNA component and a protein component and has been identified in all organisms. It was one of the first catalytic RNAs identified and the first that acts as a multiple-turnover enzyme in vivo. RNase P and the ribosome are so far the only two ribozymes known to be conserved in all kingdoms of life. The RNA component of bacterial RNase P can catalyse pre-tRNA cleavage in the absence of the RNase P protein in vitro and consists of two domains: a specificity domain and a catalytic domain. Here we report a 3.15-A resolution crystal structure of the 154-nucleotide specificity domain of Bacillus subtilis RNase P. The structure reveals the architecture of this domain, the interactions that maintain the overall fold of the molecule, a large non-helical but well-structured module that is conserved in all RNase P RNA, and the regions that are involved in interactions with the substrate.

==About this Structure==
1NBS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBS OCA]. 

==Reference==
Crystal structure of the specificity domain of ribonuclease P., Krasilnikov AS, Yang X, Pan T, Mondragon A, Nature. 2003 Feb 13;421(6924):760-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12610630 12610630]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Krasilnikov, A S.]]
[[Category: Mondragon, A.]]
[[Category: Pan, T.]]
[[Category: Yang, X.]]
[[Category: MG]]
[[Category: PB]]
[[Category: p rna]]
[[Category: ribonuclease p rna]]
[[Category: s-domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:54:46 2008''