View source for 3ko1

==Cystal structure of thermosome from Acidianus tengchongensis strain S5==
<StructureSection load='3ko1' size='340' side='right' caption='[[3ko1]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ko1]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Acidianus_tengchongensis Acidianus tengchongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KO1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ko1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ko1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ko1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ko1 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Thermosomes are group II chaperonins responsible for protein refolding in an ATP-dependent manner. Little is known regarding the conformational changes of thermosomes during their functional cycle due to a lack of high-resolution structure in the open state. Here, we report the first complete crystal structure of thermosome (rATcpnbeta) in the open state from Acidianus tengchongensis. There is a approximately 30 degrees rotation of the apical and lid domains compared with the previous closed structure. Besides, the structure reveals a conspicuous hydrophobic patch in the lid domain, and residues locating in this patch are conserved across species. Both the closed and open forms of rATcpnbeta were also reconstructed by electron microscopy (EM). Structural fitting revealed the detailed conformational change from the open to the closed state. Structural comparison as well as protease K digestion indicated only ATP binding without hydrolysis does not induce chamber closure of thermosome.

Crystal structure of group II chaperonin in the open state.,Huo Y, Hu Z, Zhang K, Wang L, Zhai Y, Zhou Q, Lander G, Zhu J, He Y, Pang X, Xu W, Bartlam M, Dong Z, Sun F Structure. 2010 Oct 13;18(10):1270-9. PMID:20947016<ref>PMID:20947016</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>

==See Also==
*[[Chaperonin|Chaperonin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acidianus tengchongensis]]
[[Category: Dong, Z]]
[[Category: He, Y]]
[[Category: Hu, Z]]
[[Category: Huo, Y]]
[[Category: Lander, G]]
[[Category: Sun, F]]
[[Category: Wang, L]]
[[Category: Xu, W]]
[[Category: Zhai, Y]]
[[Category: Zhang, K]]
[[Category: Zhou, Q]]
[[Category: Zhu, J]]
[[Category: 9-fold symmetry]]
[[Category: Atp hydrolase]]
[[Category: Chaperone]]
[[Category: Double ring]]
[[Category: Nucleotide-binding]]