View source for 1miz

[[Image:1miz.gif|left|200px]]

 {{Structure
|PDB= 1miz |SIZE=350|CAPTION= <scene name='initialview01'>1miz</scene>, resolution 1.90&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''Crystal structure of an integrin beta3-talin chimera'''


==Overview==
The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.

==Disease==
Known diseases associated with this structure: Glanzmann thrombasthenia, type B OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173470 173470]]

==About this Structure==
1MIZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MIZ OCA]. 

==Reference==
Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12535520 12535520]
[[Category: Gallus gallus]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Calderwood, D A.]]
[[Category: Campbell, I D.]]
[[Category: Critchley, D.]]
[[Category: Garcia-Alvarez, B.]]
[[Category: Ginsberg, M H.]]
[[Category: Liddington, R C.]]
[[Category: Pereda, J M.de.]]
[[Category: Ulmer, T S.]]
[[Category: cytoskeleton]]
[[Category: focal adhesion]]
[[Category: integrin binding]]
[[Category: npxy motif]]
[[Category: ptb domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:44:01 2008''