View source for 2ov2

==The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)==
<StructureSection load='2ov2' size='340' side='right' caption='[[2ov2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ov2]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OV2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2g0n|2g0n]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PAK4, KIAA1142 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ov2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ov2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ov2 PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/2ov2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H.]]
[[Category: Bunkoczi, G.]]
[[Category: Burgess-Brown, N.]]
[[Category: Debreczeni, J E.D.]]
[[Category: Delft, F von.]]
[[Category: Doyle, D A.]]
[[Category: Edwards, A.]]
[[Category: Elkins, J M.]]
[[Category: Knapp, S.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt, J.]]
[[Category: Yang, X.]]
[[Category: Crib]]
[[Category: Gtpase rac3]]
[[Category: Kinase]]
[[Category: P21 rac]]
[[Category: Protein binding-transferase complex]]
[[Category: Ras-related c3 botulinum toxin substrate 3]]
[[Category: Sgc]]
[[Category: Signalling protein]]
[[Category: Small gtp binding protein]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]