View source for 2g62

==Crystal structure of human PTPA==
<StructureSection load='2g62' size='340' side='right' caption='[[2g62]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2g62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G62 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPP2R4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g62 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g62 RCSB], [http://www.ebi.ac.uk/pdbsum/2g62 PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g62_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Protein phosphatase 2A (PP2A) is a heterotrimeric Ser/Thr phosphatase that is involved in regulating a plethora of signaling pathways in the cell, making its regulation a critical part of the well being of the cell. For example, three of the non-catalytic PP2A subunits have been linked to carcinogenic events. Therefore, the molecular basis for the complicated protein-protein interaction pattern of PP2A and its regulators is of special interest. The PP2A phosphatase activator (PTPA) protein is highly conserved from humans to yeast. It is an activator of PP2A and has been shown to be essential for a fully functional PP2A, but its mechanism of activation is still not well defined. We have solved the crystal structure of human PTPA to 1.6A. It reveals a two-domain protein with a novel fold comprised of 13 alpha-helices. We have identified a highly conserved cleft as a potential region for interaction with peptide segments of other proteins. Binding studies with ATP and its analogs are not consistent with ATP being a cofactor/substrate for PTPA as had previously been proposed. The structure of PTPA can serve as a basis for structure-function studies directed at elucidating its mechanism as an activator of PP2A.

The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.,Magnusdottir A, Stenmark P, Flodin S, Nyman T, Hammarstrom M, Ehn M, Bakali H MA, Berglund H, Nordlund P J Biol Chem. 2006 Aug 11;281(32):22434-8. Epub 2006 Jun 16. PMID:16782712<ref>PMID:16782712</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>

==See Also==
*[[Protein phosphatase|Protein phosphatase]]
*[[Serine/threonine protein phosphatase|Serine/threonine protein phosphatase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Berg, S Van Den.]]
[[Category: Berglund, H.]]
[[Category: Collins, R.]]
[[Category: Edwards, A.]]
[[Category: Ehn, M.]]
[[Category: Flodin, S.]]
[[Category: Flores, A.]]
[[Category: G Thorsell, A.]]
[[Category: Graslund, S.]]
[[Category: Hallberg, B M.]]
[[Category: Hammarstrom, M.]]
[[Category: Hogbom, M.]]
[[Category: Kotenyova, T.]]
[[Category: Magnusdottir, A.]]
[[Category: Nilsson-Ehle, P.]]
[[Category: Nordlund, P.]]
[[Category: Nyman, T.]]
[[Category: Ogg, D.]]
[[Category: Persson, C.]]
[[Category: Sagemark, J.]]
[[Category: Schiavone, L Holmberg.]]
[[Category: Stenmark, P.]]
[[Category: Sundstrom, M.]]
[[Category: Wallden, K.]]
[[Category: Weigelt, J.]]
[[Category: Hydrolase activator]]
[[Category: Mgc2184]]
[[Category: Pp2a]]
[[Category: Ppp2r4]]
[[Category: Pr53]]
[[Category: Protein phosphatase 2a]]
[[Category: Ptpa]]