View source for 2bgn

[[Image:2bgn.gif|left|200px]]<br />
<applet load="2bgn" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bgn, resolution 3.15&Aring;" />
'''HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE TRP2-TAT (1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)'''<br />

==Overview==
CD26 or dipeptidyl-peptidase IV (DPPIV) is engaged in immune functions by, co-stimulatory effects on activation and proliferation of T lymphocytes, binding to adenosine deaminase, and regulation of various chemokines and, cytokines. DPPIV peptidase activity is inhibited by both Tat protein from, human immunodeficiency virus (HIV)-1 and its N-terminal nonapeptide, Tat-(1-9) with amino acid sequence MDPVDPNIE, suggesting that DPPIV, mediates immunosuppressive effects of Tat protein. The 2.0- and 3.15-A, resolution crystal structures of the binary complex between human DPPIV, and nonapeptide Tat-(1-9) and the ternary complex between the variant, MWPVDPNIE, called Trp(2)-Tat-(1-9), and DPPIV bound to adenosine deaminase, show that Tat-(1-9) and Trp(2)-Tat-(1-9) are located in the active site ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15695814 (full description)]]

==About this Structure==
2BGN is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGN OCA]]. 

==Reference==
Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26)., Weihofen WA, Liu J, Reutter W, Saenger W, Fan H, J Biol Chem. 2005 Apr 15;280(15):14911-7. Epub 2005 Jan 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15695814 15695814]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Fan, H.]]
[[Category: Liu, J.]]
[[Category: Reutter, W.]]
[[Category: Saenger, W.]]
[[Category: Weihofen, W.A.]]
[[Category: NAG]]
[[Category: ZN]]
[[Category: ada]]
[[Category: adenosine deaminase]]
[[Category: alpha/beta-hydrolase fold]]
[[Category: aminopeptidase]]
[[Category: beta-propeller fold]]
[[Category: cd26]]
[[Category: dipetidyl peptidase iv]]
[[Category: dppiv]]
[[Category: hiv-1 tat protein]]
[[Category: protein-protein complex]]
[[Category: serine protease]]

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