View source for 1hnr

[[Image:1hnr.jpg|left|200px]]

 {{Structure
|PDB= 1hnr |SIZE=350|CAPTION= <scene name='initialview01'>1hnr</scene>
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''H-NS (DNA-BINDING DOMAIN)'''


==Overview==
The three-dimensional structure of the C-terminal domain (47 residues) obtained from the hydrolysis of H-NS protein with bovine trypsin was determined by NMR measurements and distance geometry calculations. It is composed of an antiparallel beta-sheet, an alpha-helix and a 3(10)-helix which form a hydrophobic core, stabilizing the whole structure. This domain has been found to bind to DNA. Possible DNA binding sites are discussed on the basis of the solution structure of the C-terminal domain of H-NS.

==About this Structure==
1HNR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNR OCA]. 

==Reference==
Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coli., Shindo H, Iwaki T, Ieda R, Kurumizaka H, Ueguchi C, Mizuno T, Morikawa S, Nakamura H, Kuboniwa H, FEBS Lett. 1995 Feb 27;360(2):125-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7875316 7875316]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Ieda, R.]]
[[Category: Iwaki, T.]]
[[Category: Kuboniwa, H.]]
[[Category: Kurumizaka, H.]]
[[Category: Mizuno, T.]]
[[Category: Morikawa, S.]]
[[Category: Nakamura, H.]]
[[Category: Shindo, H.]]
[[Category: Ueguchi, C.]]
[[Category: histone-like protein h1]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:39:24 2008''