View source for 1ewl

==CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99==
<StructureSection load='1ewl' size='340' side='right' caption='[[1ewl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ewl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EWL FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R99:N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE'>R99</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aim|1aim]], [[2aim|2aim]], [[1ewm|1ewm]], [[1ewo|1ewo]], [[1ewp|1ewp]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ewl RCSB], [http://www.ebi.ac.uk/pdbsum/1ewl PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Cruzain|Cruzain]]
__TOC__
</StructureSection>
[[Category: Trypanosoma cruzi]]
[[Category: Brinen, L S.]]
[[Category: Fletterick, R J.]]
[[Category: Gillmor, S A.]]
[[Category: Covalent inhibitor]]
[[Category: Cruzipain]]
[[Category: Drug design]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Papain-like cysteine protease]]