View source for 2zn7

==CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes==
<StructureSection load='2zn7' size='340' side='right' caption='[[2zn7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2zn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZN7 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=410:4-BROMO-3-(CARBOXYMETHOXY)-5-{3-[CYCLOHEXYL(PHENYLCARBONYL)AMINO]PHENYL}THIOPHENE-2-CARBOXYLIC+ACID'>410</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zmm|2zmm]], [[2qbq|2qbq]], [[2bo7|2bo7]]</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zn7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zn7 RCSB], [http://www.ebi.ac.uk/pdbsum/2zn7 PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/2zn7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Wu, J.]]
[[Category: Xu, W.]]
[[Category: Endoplasmic reticulum]]
[[Category: Hydrolase]]
[[Category: Membrane]]
[[Category: Oxidation]]
[[Category: Phosphoprotein]]
[[Category: Protein phosphatase]]
[[Category: Protein-inhibitor complex]]
[[Category: Ptp1b]]