View source for 1exb

[[Image:1exb.gif|left|200px]]

 {{Structure
|PDB= 1exb |SIZE=350|CAPTION= <scene name='initialview01'>1exb</scene>, resolution 2.1&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE'>NDP</scene>
|ACTIVITY= 
|GENE= 
}}

'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''


==Overview==
The structure of the cytoplasmic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane alpha subunit together with the oxidoreductase beta subunit in a fourfold symmetric T1(4)beta4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four beta subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1(4)beta4 complex. The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings.

==About this Structure==
1EXB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXB OCA]. 

==Reference==
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10884227 10884227]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Gulbis, J M.]]
[[Category: MacKinnon, R.]]
[[Category: Mann, S.]]
[[Category: Zhou, M.]]
[[Category: NDP]]
[[Category: beta subunit]]
[[Category: ion channel]]
[[Category: oxidoreductase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:01:27 2008''