View source for 2ciw

[[Image:2ciw.gif|left|200px]]<br />
<applet load="2ciw" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2ciw, resolution 1.15&Aring;" />
'''CHLOROPEROXIDASE IODIDE COMPLEX'''<br />

==Overview==
Chloroperoxidase (CPO) is a heme-thiolate enzyme that catalyzes hydrogen, peroxide-dependent halogenation reactions. Structural data on substrate, binding have not been available so far. CPO was therefore crystallized in, the presence of iodide or bromide. One halide binding site was identified, at the surface near a narrow channel that connects the surface with the, heme. Two other halide binding sites were identified within and at the, other end of this channel. Together, these sites suggest a pathway for, access of halide anions to the active site. The structure of CPO complexed, with its natural substrate cyclopentanedione was determined at a, resolution of 1.8 A. This is the first example of a CPO structure with a, bound organic substrate. In addition, structures of CPO bound with, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16790441 (full description)]]

==About this Structure==
2CIW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Leptoxyphium_fumago Leptoxyphium fumago]] with NAG, MAN, MN, IOD and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CIW OCA]]. 

==Reference==
Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate., Kuhnel K, Blankenfeldt W, Terner J, Schlichting I, J Biol Chem. 2006 Aug 18;281(33):23990-8. Epub 2006 Jun 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16790441 16790441]
[[Category: Chloride peroxidase]]
[[Category: Leptoxyphium fumago]]
[[Category: Single protein]]
[[Category: Blankenfeldt, W.]]
[[Category: Kuhnel, K.]]
[[Category: Schlichting, I.]]
[[Category: Terner, J.]]
[[Category: HEM]]
[[Category: IOD]]
[[Category: MAN]]
[[Category: MN]]
[[Category: NAG]]
[[Category: chloride]]
[[Category: glycoprotein]]
[[Category: heme]]
[[Category: iron]]
[[Category: manganese]]
[[Category: metal-binding]]
[[Category: oxidoreductase]]
[[Category: peroxidase]]
[[Category: pyrrolidone carboxylic acid]]

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