View source for 2c9t

[[Image:2c9t.gif|left|200px]]<br />
<applet load="2c9t" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2c9t, resolution 2.25&Aring;" />
'''CRYSTAL STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) FROM APLYSIA CALIFORNICA IN COMPLEX WITH ALPHA-CONOTOXIN IMI'''<br />

==Overview==
The nicotinic acetylcholine receptor (nAChR) is the prototype member of, the superfamily of pentameric ligand-gated ion channels. How the, extracellular ligand-binding domain coordinates selective binding of, ligand molecules to different subtypes of the receptor is unknown at the, structural level. Here, we present the 2.2-A crystal structure of a, homolog of the ligand-binding domain of the nAChR, Aplysia californica, AChBP (Ac-AChBP), in complex with alpha-conotoxin ImI. This conotoxin is, unique in its selectivity toward the neuronal alpha3beta2 and alpha7, nAChR, a feature that is reflected in its selective binding to Ac-AChBP, compared with other AChBP homologs. We observe a network of interactions, between the residues of the ligand-binding site and the toxin, in which, ImI Arg-7 ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16505382 (full description)]]

==About this Structure==
2C9T is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]] and [[http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]] with NH2 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C9T OCA]]. 

==Reference==
Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP., Ulens C, Hogg RC, Celie PH, Bertrand D, Tsetlin V, Smit AB, Sixma TK, Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3615-20. Epub 2006 Feb 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16505382 16505382]
[[Category: Aplysia californica]]
[[Category: Conus imperialis]]
[[Category: Protein complex]]
[[Category: Bertrand, D.]]
[[Category: Celie, P.H.]]
[[Category: Hogg, R.]]
[[Category: Sixma, T.K.]]
[[Category: Smit, A.B.]]
[[Category: Tsetlin, V.]]
[[Category: Ulens, C.]]
[[Category: NH2]]
[[Category: acetylcholine binding protein]]
[[Category: acetylcholine receptor inhibitor]]
[[Category: amidation]]
[[Category: conformational flexibility]]
[[Category: conotoxin]]
[[Category: neurotoxin]]
[[Category: nicotinic acetylcholine receptor/toxin complex]]
[[Category: postsynaptic neurotoxin]]
[[Category: toxin]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:02:46 2007''