View source for 4aed

==Crystal structure of Human enterovirus 71==
<StructureSection load='4aed' size='340' side='right' caption='[[4aed]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4aed]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_enterovirus_71 Human enterovirus 71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AED FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene><br>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aed OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aed RCSB], [http://www.ebi.ac.uk/pdbsum/4aed PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the canyon. Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

Crystal Structure of Human Enterovirus 71.,Plevka P, Perera R, Cardosa J, Kuhn RJ, Rossmann MG Science. 2012 Mar 1. PMID:22383808<ref>PMID:22383808</ref>

From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human enterovirus 71]]
[[Category: Kuhn, R J.]]
[[Category: Perera, R.]]
[[Category: Plevka, P.]]
[[Category: Rossmann, M G.]]
[[Category: Capsid]]
[[Category: Pathogen]]
[[Category: Picornavirus]]
[[Category: Virus]]