View source for 1aoy

[[Image:1aoy.jpg|left|200px]]

 {{Structure
|PDB= 1aoy |SIZE=350|CAPTION= <scene name='initialview01'>1aoy</scene>
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''N-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR NMR, 23 STRUCTURES'''


==Overview==
The structure of the monomeric DNA-binding domain of the Escherichia coli arginine repressor, ArgR, determined by NMR spectroscopy, shows structural homology to the winged helix-turn-helix (wHTH) family, a motif found in a diverse class of proteins including both gene regulators and gene organizers from prokaryotes and eukaryotes. Biochemical data on DNA binding by intact ArgR are used as constraints to position the domain on its DNA target and to derive a model for the hexamer-DNA complex using the known structure of the L-arginine-binding domain. The structural independence of the wHTH fold may be important for multimeric DNA-binding proteins that contact extended DNA regions with imperfect match to consensus sequences, a feature of many wHTH-domain proteins.

==About this Structure==
1AOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOY OCA]. 

==Reference==
Solution structure of the DNA-binding domain and model for the complex of multifunctional hexameric arginine repressor with DNA., Sunnerhagen M, Nilges M, Otting G, Carey J, Nat Struct Biol. 1997 Oct;4(10):819-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334747 9334747]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Nilges, M.]]
[[Category: Otting, G.]]
[[Category: Sunnerhagen, M.]]
[[Category: dna organization]]
[[Category: dna-binding protein]]
[[Category: expression regulation]]
[[Category: winged helix]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:28 2008''