View source for 2byr

[[Image:2byr.gif|left|200px]]<br />
<applet load="2byr" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2byr, resolution 2.45&Aring;" />
'''CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA IN COMPLEX WITH METHYLLYCACONITINE'''<br />

==Overview==
Upon ligand binding at the subunit interfaces, the extracellular domain of, the nicotinic acetylcholine receptor undergoes conformational changes, and, agonist binding allosterically triggers opening of the ion channel. The, soluble acetylcholine-binding protein (AChBP) from snail has been shown to, be a structural and functional surrogate of the ligand-binding domain, (LBD) of the receptor. Yet, individual AChBP species display disparate, affinities for nicotinic ligands. The crystal structure of AChBP from, Aplysia californica in the apo form reveals a more open loop C and, distinctive positions for other surface loops, compared with previous, structures. Analysis of Aplysia AChBP complexes with nicotinic ligands, shows that loop C, which does not significantly change conformation upon, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16193063 (full description)]]

==About this Structure==
2BYR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]] with MLK as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BYR OCA]]. 

==Reference==
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations., Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y, EMBO J. 2005 Oct 19;24(20):3635-46. Epub 2005 Sep 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16193063 16193063]
[[Category: Aplysia californica]]
[[Category: Single protein]]
[[Category: Author]]
[[Category: Bourne, Y.]]
[[Category: Hansen, S.B.]]
[[Category: Huxford, T.]]
[[Category: Marchot, P.]]
[[Category: Sulzenbacher, G.]]
[[Category: Taylor, P.]]
[[Category: MLK]]
[[Category: acetylcholine binding protein]]
[[Category: conformational flexibility methyllycaconitine]]
[[Category: nicotinic acetylcholine receptor]]
[[Category: receptor]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:52:33 2007''