View source for 4pvs

{{STRUCTURE_4pvs|  PDB=4pvs  |  SCENE=  }} 
===Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate===
{{ABSTRACT_PUBMED_22861376}}

==Function==
[[http://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN]] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref>  

==About this Structure==
[[4pvs]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gdw 4gdw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVS OCA]. 

==Reference==
<ref group="xtra">PMID:022861376</ref><references group="xtra"/><references/>
[[Category: Lavie, A.]]
[[Category: Nomme, J.]]
[[Category: Homodimer]]
[[Category: Hydrolase]]
[[Category: L-asparagine]]
[[Category: Ntn enzyme]]