View source for 4nuv

{{STRUCTURE_4nuv|  PDB=4nuv  |  SCENE=  }} 
===Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)===
{{ABSTRACT_PUBMED_24415938}}

==Function==
[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. 

==About this Structure==
[[4nuv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUV OCA]. 

==Reference==
<ref group="xtra">PMID:024415938</ref><references group="xtra"/><references/>
[[Category: Tolia, N H.]]
[[Category: Adhesion]]
[[Category: Cell invasion]]
[[Category: Chemokine binding]]
[[Category: Duffy antigen receptor for chemokine]]
[[Category: Gpcr]]
[[Category: Invasion]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Protein binding]]
[[Category: Red blood cell binding]]