View source for 3b3f

[[Image:3b3f.gif|left|200px]]<br /><applet load="3b3f" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="3b3f, resolution 2.20&Aring;" />
'''The 2.2 A crystal structure of the catalytic domain of coactivator-associated arginine methyl transferase I(CARM1,142-478), in complex with S-adenosyl homocysteine'''<br />

==Overview==
Coactivator-associated arginine methyltransferase 1 (CARM1), a protein arginine methyltransferase recruited by several transcription factors, methylates a large variety of proteins and plays a critical role in gene expression. We report, in this paper, four crystal structures of isolated modules of CARM1. The 1.7 A crystal structure of the N-terminal domain of CARM1 reveals an unexpected PH domain, a scaffold frequently found to regulate protein-protein interactions in a large variety of biological processes. Three crystal structures of the CARM1 catalytic module, two free and one cofactor-bound forms (refined at 2.55 A, 2.4 A and 2.2 A, respectively) reveal large structural modifications including disorder to order transition, helix to strand transition and active site modifications. The N-terminal and the C-terminal end of CARM1 catalytic module contain molecular switches that may inspire how CARM1 regulates its biological activities by protein-protein interactions.

==About this Structure==
3B3F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=SAH:'>SAH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B3F OCA]. 

==Reference==
Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains., Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J, EMBO J. 2007 Oct 17;26(20):4391-401. Epub 2007 Sep 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17882262 17882262]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Cavarelli, J.]]
[[Category: Cura, V.]]
[[Category: Hassenboehler, P.]]
[[Category: Moras, D.]]
[[Category: Troffer-Charlier, N.]]
[[Category: SAH]]
[[Category: alternative splicing]]
[[Category: catalytic domain]]
[[Category: chromatin regulator]]
[[Category: cytoplasm]]
[[Category: mrna processing]]
[[Category: mrna splicing]]
[[Category: nucleus]]
[[Category: protein arginine methyltransferase]]
[[Category: s-adenosyl-l-methionine]]
[[Category: transcription]]
[[Category: transcription regulation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:03:00 2008''