View source for 4lbo

{{STRUCTURE_4lbo|  PDB=4lbo  |  SCENE=  }} 
===Crystal structure of Human galectin-3 CRD in complex with a-GM3===
{{ABSTRACT_PUBMED_24326249}}

==Function==
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>  

==About this Structure==
[[4lbo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LBO OCA]. 

==Reference==
<ref group="xtra">PMID:024326249</ref><references group="xtra"/><references/>
[[Category: Blanchard, H.]]
[[Category: Collins, P M.]]
[[Category: Beta sandwich]]
[[Category: Carbohydrate binding protein]]
[[Category: Carbohydrate-recognition]]
[[Category: Galectin]]
[[Category: Glycosphingolipid]]
[[Category: Gm3]]
[[Category: Sugar binding protein]]