View source for 4mn4

{{STRUCTURE_4mn4|  PDB=4mn4  |  SCENE=  }} 
===Structural Basis for the MukB-topoisomerase IV Interaction===
{{ABSTRACT_PUBMED_24097060}}

==Function==
[[http://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref>  [[http://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI]] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>  

==About this Structure==
[[4mn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_mg1655 Escherichia coli mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA]. 

==Reference==
<ref group="xtra">PMID:024097060</ref><references group="xtra"/><references/>
[[Category: Escherichia coli mg1655]]
[[Category: Berger, J M.]]
[[Category: Oakley, M G.]]
[[Category: Stewart, N K.]]
[[Category: Vos, S M.]]
[[Category: Beta-pinwheel]]
[[Category: Chromosome partitioning]]
[[Category: Isomerase-cell cycle complex]]