View source for 3h7d

{{STRUCTURE_3h7d|  PDB=3h7d  |  SCENE=  }} 
===The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate===
{{ABSTRACT_PUBMED_21193413}}

==Disease==
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>  

==Function==
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. 

==About this Structure==
[[3h7d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7D OCA]. 

==See Also==
*[[Cathepsin|Cathepsin]]

==Reference==
<ref group="xtra">PMID:021193413</ref><references group="xtra"/><references/>
[[Category: Cathepsin K]]
[[Category: Human]]
[[Category: Bromme, D.]]
[[Category: Cherney, M M.]]
[[Category: James, M N.G.]]
[[Category: Kienetz, M.]]
[[Category: Cathepsin k mutant]]
[[Category: Disease mutation]]
[[Category: Disulfide bond]]
[[Category: Glycoprotein]]
[[Category: Glycosaminoglycan]]
[[Category: Hydrolase]]
[[Category: Lysosome]]
[[Category: Protease]]
[[Category: Sulfhydryl peptidase]]
[[Category: Ternary complex]]
[[Category: Thiol protease]]
[[Category: Zymogen]]