View source for 4lx0

{{STRUCTURE_4lx0|  PDB=4lx0  |  SCENE=  }} 
===Crystal structure of Myo5b globular tail domain in complex with active Rab11a===
{{ABSTRACT_PUBMED_24248336}}

==Disease==
[[http://www.uniprot.org/uniprot/MYO5B_HUMAN MYO5B_HUMAN]] Microvillous inclusion disease. The disease is caused by mutations affecting the gene represented in this entry. 

==Function==
[[http://www.uniprot.org/uniprot/RB11A_HUMAN RB11A_HUMAN]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.<ref>PMID:15601896</ref> <ref>PMID:15689490</ref> <ref>PMID:17462998</ref> <ref>PMID:19542231</ref> <ref>PMID:20890297</ref> <ref>PMID:21282656</ref>  [[http://www.uniprot.org/uniprot/MYO5B_HUMAN MYO5B_HUMAN]] May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity).<ref>PMID:17462998</ref> <ref>PMID:19542231</ref> <ref>PMID:21282656</ref>  

==About this Structure==
[[4lx0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LX0 OCA]. 

==Reference==
<ref group="xtra">PMID:024248336</ref><references group="xtra"/><references/>
[[Category: Human]]
[[Category: Attanda, W.]]
[[Category: Gauquelin, C.]]
[[Category: Houdusse, A.]]
[[Category: Pylypenko, O.]]
[[Category: Dil]]
[[Category: Protein transport-contractile protein complex]]