View source for 1xgo

[[Image:1xgo.gif|left|200px]]<br />
<applet load="1xgo" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1xgo, resolution 3.5&Aring;" />
'''METHIONINE AMINOPEPTIDASE FROM HYPERTHERMOPHILE PYROCOCCUS FURIOSUS'''<br />

==Overview==
The structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus (PfMAP) with an optimal growth temperature of 100, degreesC was determined by the multiple isomorphous replacement method and, refined in three different crystal forms, one monoclinic and two, hexagonal, at resolutions of 2.8, 2.9, and 3.5 A. The resolution of the, monoclinic crystal form was extended to 1.75 A by water-mediated, transformation to a low-humidity form, and the obtained diffraction data, used for high-resolution structure refinement. This is the first, description of a eukaryotic type methionine aminopeptidase structure. The, PfMAP molecule is composed of two domains, a catalytic domain and an, insertion domain, connected via two antiparallel beta-strands. The, catalytic domain, which ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9811545 (full description)]]

==About this Structure==
1XGO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]]. Active as [[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18]]. Structure known Active Site: AC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XGO OCA]]. 

==Reference==
Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus., Tahirov TH, Oki H, Tsukihara T, Ogasahara K, Yutani K, Ogata K, Izu Y, Tsunasawa S, Kato I, J Mol Biol. 1998 Nov 20;284(1):101-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9811545 9811545]
[[Category: Methionyl aminopeptidase]]
[[Category: Pyrococcus furiosus]]
[[Category: Single protein]]
[[Category: Tahirov, T.H.]]
[[Category: Tsukihara, T.]]
[[Category: aminopeptidase]]
[[Category: hyperthermophile]]

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