View source for 4lax

{{STRUCTURE_4lax|  PDB=4lax  |  SCENE=  }} 
===Crystal Structure Analysis of FKBP52, Complex with FK506===
{{ABSTRACT_PUBMED_23933011}}

==Function==
[[http://www.uniprot.org/uniprot/FKBP4_HUMAN FKBP4_HUMAN]] Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<ref>PMID:1279700</ref> <ref>PMID:1376003</ref> <ref>PMID:2378870</ref> <ref>PMID:19945390</ref> <ref>PMID:21730050</ref>  

==About this Structure==
[[4lax]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LAX OCA]. 

==Reference==
<ref group="xtra">PMID:023933011</ref><references group="xtra"/><references/>
[[Category: Human]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Bracher, A.]]
[[Category: Haehle, A.]]
[[Category: Hausch, F.]]
[[Category: Kozany, C.]]
[[Category: Wild, P.]]
[[Category: Zacharias, M.]]
[[Category: Fk-506 binding domain]]
[[Category: Hsp90 cochaperone]]
[[Category: Immunophilin]]
[[Category: Isomerase]]
[[Category: Peptidyl-prolyl isomerase]]
[[Category: Protein folding]]