View source for 4m49

{{STRUCTURE_4m49|  PDB=4m49  |  SCENE=  }} 
===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18===
{{ABSTRACT_PUBMED_24012183}}

==Disease==
[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>  

==About this Structure==
[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. 

==Reference==
<ref group="xtra">PMID:024012183</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: L-lactate dehydrogenase]]
[[Category: Eigenbrot, C.]]
[[Category: Ultsch, M.]]
[[Category: Dehydrogenase/reductase]]
[[Category: Nicotinamide adenine dinucleotide nadh]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]