View source for 4lxe

{{STRUCTURE_4lxe|  PDB=4lxe  |  SCENE=  }} 
===Bcl_2-Navitoclax Analog (with Indole) Complex===
{{ABSTRACT_PUBMED_23291630}}

==Disease==
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. 

==Function==
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>  

==About this Structure==
[[4lxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXE OCA]. 

==Reference==
<ref group="xtra">PMID:023291630</ref><references group="xtra"/><references/>
[[Category: Ochroconis lascauxensis]]
[[Category: Park, C H.]]
[[Category: 8 helice]]
[[Category: Apoptosis regulator-inhibitor complex]]