View source for 4lr6

{{STRUCTURE_4lr6|  PDB=4lr6  |  SCENE=  }} 
===Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment===

==Disease==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  

==Function==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). 

==About this Structure==
[[4lr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LR6 OCA]. 

==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Albrecht, B.]]
[[Category: Audia, J.]]
[[Category: Bellon, S.]]
[[Category: Bergeron, L.]]
[[Category: Birudukota, S.]]
[[Category: Bryant, B.]]
[[Category: Cote, A.]]
[[Category: Gehling, V.]]
[[Category: Harmange, J C.]]
[[Category: Hewitt, M.]]
[[Category: Jayaram, H.]]
[[Category: Joshi, S.]]
[[Category: Leblanc, Y.]]
[[Category: Mertz, J.]]
[[Category: Nandana, B S.]]
[[Category: Nasveschuk, C.]]
[[Category: Pardo, E.]]
[[Category: Poy, F.]]
[[Category: Sandy, P.]]
[[Category: Sankaranarayanan, R.]]
[[Category: Sims, R.]]
[[Category: Taylor, A.]]
[[Category: Vaswani, R.]]
[[Category: Yellapuntala, S.]]
[[Category: Bet inhibitor]]
[[Category: Brd4 first bromodomain]]
[[Category: Transcription regulator-inhibitor complex]]