View source for 4etp

{{STRUCTURE_4etp|  PDB=4etp  |  SCENE=  }} 
===C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil===
{{ABSTRACT_PUBMED_22734002}}

==Function==
[[http://www.uniprot.org/uniprot/KAR3_YEAST KAR3_YEAST]] Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.<ref>PMID:2138512</ref> <ref>PMID:11729143</ref>  [[http://www.uniprot.org/uniprot/VIK1_YEAST VIK1_YEAST]] Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.<ref>PMID:10087265</ref> <ref>PMID:11729143</ref>  

==About this Structure==
[[4etp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETP OCA]. 

==Reference==
<ref group="xtra">PMID:022734002</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Chen, C J.]]
[[Category: Cope, J.]]
[[Category: Gilbert, S P.]]
[[Category: Hoenger, A.]]
[[Category: Porche, K.]]
[[Category: Rank, K C.]]
[[Category: Rayment, I.]]
[[Category: Internal vik1 crosslink with n]]
[[Category: Karyogamy]]
[[Category: Kinesin motor homology domain]]
[[Category: Kinesin motor protein]]
[[Category: Microtubule]]
[[Category: Mitosis]]
[[Category: Motor protein]]
[[Category: Nucleus]]