View source for 2iui

[[Image:2iui.gif|left|200px]]<br /><applet load="2iui" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="2iui, resolution 2.40&Aring;" />
'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE'''<br />

==Overview==
Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners.

==About this Structure==
2IUI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUI OCA]. 

==Reference==
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes., Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC, Nat Struct Biol. 1996 Apr;3(4):364-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8599763 8599763]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Eck, M J.]]
[[Category: Harrison, S C.]]
[[Category: Nolte, R T.]]
[[Category: Schlessinger, J.]]
[[Category: Shoelson, S E.]]
[[Category: disease mutation]]
[[Category: p85]]
[[Category: phosphorylation]]
[[Category: pi3-kinase]]
[[Category: pi3k]]
[[Category: polymorphism]]
[[Category: sh2]]
[[Category: sh2 domain]]
[[Category: sh3 domain]]
[[Category: transferase]]
[[Category: ubl conjugation]]

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