View source for 1uxw

[[Image:1uxw.gif|left|200px]]<br />
<applet load="1uxw" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1uxw, resolution 1.71&Aring;" />
'''CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE LATENT MEMBRANE PROTEIN 2 PEPTIDE (LMP2) OF EPSTEIN-BARR VIRUS'''<br />

==Overview==
Molecular mimicry is discussed as a possible mechanism that may contribute, to the development of autoimmune diseases. It could also be involved in, the differential association of the human major histocompatibility, subtypes HLA-B(*)2705 and HLA-B(*)2709 with ankylosing spondylitis. These, two subtypes differ only in residue 116 of the heavy chain (Asp in, B(*)2705 and His in B(*)2709), but the reason for the differential disease, association is not understood. Using x-ray crystallography, we show here, that the viral peptide pLMP2 (RRRWRRLTV, derived from latent membrane, protein 2 (residues 236-244) of Epstein-Barr virus) is presented by the, B(*)2705 and B(*)2709 molecules in two drastically deviating, conformations. Extensive structural similarity between pLMP2 and the, self-peptide ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15537660 (full description)]]

==About this Structure==
1UXW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UXW OCA]]. 

==Reference==
Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes., Fiorillo MT, Ruckert C, Hulsmeyer M, Sorrentino R, Saenger W, Ziegler A, Uchanska-Ziegler B, J Biol Chem. 2005 Jan 28;280(4):2962-71. Epub 2004 Nov 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15537660 15537660]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Fiorillo, M.T.]]
[[Category: Hulsmeyer, M.]]
[[Category: Kozerski, C.]]
[[Category: Saenger, W.]]
[[Category: Sorrentino, R.]]
[[Category: Uchanska-Ziegler, B.]]
[[Category: Ziegler, A.]]
[[Category: GOL]]
[[Category: hla-b*2709]]
[[Category: immune system]]
[[Category: mhc (major histocompatibility complex)]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:14:51 2007''