View source for 4ivb

{{STRUCTURE_4ivb|  PDB=4ivb  |  SCENE=  }} 
===JAK1 kinase (JH1 domain) in complex with the inhibitor TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXANECARBONITRILE===
{{ABSTRACT_PUBMED_23659214}}

==Function==
[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. 

==About this Structure==
[[4ivb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IVB OCA]. 

==Reference==
<ref group="xtra">PMID:023659214</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Eigenbrot, C.]]
[[Category: Steffek, M.]]
[[Category: Phosphotransfer]]
[[Category: Protein kinase]]
[[Category: Transferase-transferase inhibitor complex]]