View source for 4i12

{{STRUCTURE_4i12|  PDB=4i12  |  SCENE=  }} 
===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors===
{{ABSTRACT_PUBMED_23570791}}

==Function==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  

==About this Structure==
[[4i12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. 

==See Also==
*[[Beta secretase|Beta secretase]]

==Reference==
<ref group="xtra">PMID:023570791</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Brecht, E]]
[[Category: Lougheed, J C.]]
[[Category: Yao, N H.]]
[[Category: Aspartic protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]