View source for 2hur

[[Image:2hur.gif|left|200px]]<br /><applet load="2hur" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="2hur, resolution 1.62&Aring;" />
'''Escherichia coli nucleoside diphosphate kinase'''<br />

==Overview==
Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates. The subunit folding and the dimeric basic structural unit are remarkably the same for available structures but, depending on species, dimers self-associate to form hexamers or tetramers. The crystal structure of the Escherichia coli NDPK reveals a new tetrameric quaternary structure for this protein family. The two tetramers differ by the relative orientation of interacting dimers, which face either the convex or the concave side of their central sheet as in either Myxococcus xanthus (type I) or E. coli (type II), respectively. In the type II tetramer, the subunits interact by a new interface harboring a zone called the Kpn loop as in hexamers, but by the opposite face of this loop. The evolutionary conservation of the interface residues indicates that this new quaternary structure seems to be the most frequent assembly mode in bacterial tetrameric NDP kinases.

==About this Structure==
2HUR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUR OCA]. 

==Reference==
The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family., Moynie L, Giraud MF, Georgescauld F, Lascu I, Dautant A, Proteins. 2007 May 15;67(3):755-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17330300 17330300]
[[Category: Escherichia coli]]
[[Category: Nucleoside-diphosphate kinase]]
[[Category: Single protein]]
[[Category: Dautant, A.]]
[[Category: Georgescauld, F.]]
[[Category: Giraud, M F.]]
[[Category: Lascu, I.]]
[[Category: Moynie, L.]]
[[Category: SO4]]
[[Category: type ii tetramer]]

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