View source for 4di2

{{STRUCTURE_4di2|  PDB=4di2  |  SCENE=  }} 
===Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37===
{{ABSTRACT_PUBMED_22468684}}

==Function==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  

==About this Structure==
[[4di2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI2 OCA]. 

==Reference==
<ref group="xtra">PMID:022468684</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Long, A M.]]
[[Category: Whittington, D A.]]
[[Category: Alzheimer's disease]]
[[Category: App]]
[[Category: Beta-site amyloid precursor protein cleaving enzyme 1]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Memapsin-2]]
[[Category: Protease]]